immunotherapy and cellular therapy

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[Toxicities associated with checkpoint inhibitor immunotherapy - UpToDate](https://www.uptodate.com/contents/toxicities-associated-with-checkpoint-inhibitor-immunotherapy?search=irae&source=search result&selectedTitle=1~53&usage type=default&display rank=1) Science: Cancer immunotherapy using checkpoint blockade - PubMed irAE

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IMMUNE CHECKPOINT INHIBITORS (ICI)

Overview-immunotherapy and cellular therapy (Science 2018;359:1350)

irAE

CHIMERIC ANTIGEN RECEPTOR (CAR)-T CELLS | CAR-T

Overview (Nat Rev Cancer 2021;21:145)

• Autologous T cells w/ chimeric receptor: antibody variable region fused to T cell co-stimulatory intracellular signaling domains → MHC independent Ag recognition
• CAR-T cells targeting CD19 used for ALL, DLBCL, FL, MCL. Targeting B-cell maturation antigen (BCMA) for MM. Strategies for solid tumors in development.

CAR-T-Toxicity (Biol Blood Marrow Transplant 2019;25:625)

Clinical Immuno-Oncology