NOTE

🌱 created from: mycosis_fungoides

diagnosis_of_early_mycosis_fungoides

A total of 4 points is required for the diagnosis of mycosis fungoides based on any combination of points from the clinical, histopathologic, molecular biologic, and immunopathologic criteria.

Clinical

• Persistent and/or progressive patches/thin plaques
• Additional:
  1. Non-sun-exposed location
  2. Size/shape variation
  3. Poikiloderma

qv: Disorders that may cause pruritus

Histopathologic

• Superficial lymphoid infiltrate
• Additional
  • 1. Epidermotropism without spongiosis
  • 2. Lymphoid atypia

Molecular biologic

1. Clonal T cell receptor gene rearrangement

Immunopathologic

1. <50% CD2+, CD3+, and/or CD5+ T cells
2. <10% CD7+ T cells
3. Epidermal/dermal discordance of CD2, CD3, CD5, or CD7¶