Clinical manifestations of Polyarteritis nodosa

(Arth Rheum 2010;62:616):

• const. sx (80%): wt loss, fever, fatigue
• Neuro (79%): mononeuritis multiplex, peripheral neuropathies, stroke
• Musculoskeletal (64%): extremity pain, myalgias, arthralgias, arthritis
• Renal (51%): HTN, hematuria, proteinuria, renal failure; glomerulonephritis unusual
• GI (38%): abd pain, GIB/infarction, cholecystitis; GU (25%): ovarian or testicular pain
• Skin (50%): livedo reticularis, purpura, nodules, ulcers, Raynaud’s
• Ophthalmic (9%): retinal vasculitis, retinal exudates, conjunctivitis, uveitis
• Cardiac (22%): coronary arteritis, cardiomyopathy, pericarditis
• Pulmonary: rare; if lung involvement, suspect other vasculitis