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TMP-SMX of Important Antibacterial Drug Interactions

  • Warfarin
    • Increased effect of warfarin. Monitor levels closely if drugs are given concomitantly.
  • Phenytoin
    • Increased levels of phenytoin. Monitor levels closely if drugs are given concomitantly.
  • Methotrexate
    • Increased levels of methotrexate and prolonged exposure. Monitor levels closely if drugs are given concomitantly.