Definitions-sepsis and shock

Sepsis

TLDR

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.

.. Suspected (or documented) infection and an acute increase in ≥2 sepsis-related organ failure assessment (SOFA) points

Figure:

• Life-threatening organ dysfxn (SOFA ≥2) due to infection
• Quick SOFA (qSOFA): ≥2 of the following:
  • RR ≥22, 有夠喘
  • ΔMS, 有夠昏
  • SBP ≤100 mmHg 有夠低

Shock

Septic shock

• Sepsis-induced circulatory and cellular/metabolic abnormalities severe enough to ↑ mortality;
• hypotension requiring pressors for MAP ≥65 and lactate >2 despite adequate fluid resuscitation
  • 有 sepsis 而且需要用到升壓劑

Sequential Organ Failure Assessment (SOFA)

Organ dysfunction can be identified as an acute change in total SOFA score ≥2 points consequent to the infection.

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) | Critical Care Medicine | JAMA | JAMA Network

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