Drug-induced TMA

(clinically similar to TTP; Blood 2017;129:2857)

• thrombotic thrombocytopenic purpura
• Immune-mediated (Ab reacts w/ plts & endothelial cells): eg, quinine, gemcitabine?
• Direct toxicity mediated:
  • gemcitabine,
  • mitomycin,
  • tacrolimus,
  • CsA,
  • bevacizumab
• glomerular disease.md