Treatment-glomerulonephritis

(AJKD 2020;75:124 & 2020;76:265)

• If acute GN/RPGN suspected, give 500–1000 mg methylpred. IV qd × 3d ASAP while awaiting bx results.

• SLE nephritis: induction w/ steroids + cyclophosphamide (CYC) or MMF (CJASN 2017;12:825)

• ANCA ⊕ or anti-GBM: pulse steroids + CYC (or rituximab). Plasma exchange if ⊕ anti-GBM. Controversial in ANCA ⊕ only, even w/ GN or pulm hemor. (NEJM 2020;382:622).

• See “Vasculitis” for further disease-specific Rx details (eg, eculizumab for atypical HUS)