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Clinical Setting of Neutropenia-Febrile-High-Risk

  • Febrile neutropenia: Post-cancer chemotherapy or post-allogeneic bone marrow transplant patient with fever (≥38.3°C x 1 hr of sustained over 38°C) AND neutropenic (absolute neutrophil count range from <500-<1000 cells/μL)
  • High risk: Inpatient status at time of development of fever, significant medical comorbidity or clinically unstable, anticipated neutropenia of ≤100 cells/μL and ≥ 7 days, hepatic or renal insufficiency, uncontrolled/progressive cancer, pneumonia or other complex infections, mucositis grade 3-4, MASCC Risk Index score of < 21, Alemtuzumab.