Oncology-related glomerulopathy

(CJASN 2016;11:1681)

• Associations between malig (solid tumors & heme) and/or their Rx (HSCT & chemo- therapeutics) and GN, nephrotic syndrome, and thrombotic microangiopathies (TMA)

• Most common associations: membranous (solid tumors, HSCT), MCD (Hodgkin’s, solid tumors), MPGN (CLL, MM), TMA (HSCT, VEGF, anti-EGFR, CNIs, TKIs, mTOR)

• Monoclonal glomerulopathy of renal significance: Ig-mediated kidney disease by nonmalignant B or plasma cells. Workup: SPEP, sFLC, flow cytometry, IFE, BMBx.

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• glomerulonephritis

oncology