Anemia in chronic kidney disease

goal Hb 10–11.5 g/dL, worse outcomes if target higher (NEJM 2009;361:2019)

• epoetin (start 80–120 U/kg SC, divided 3×/wk) or darbepoetin (0.75 mg/kg q 2 wk)
• iron supplementation to keep transferrin sat >20% (often given IV in HD Pts).
• HIF inhib. ↑ endogenous EPO production, not yet approved (NEJM 2021;385:2313 & 2325).