Glucose-6-phosphate dehydrogenase

(G6PD) deficiency (Lancet 2008;371:64)

• X-linked defect of metabolism (G6PD mutations) w/ ↑ susceptibility to oxidative damage

• Most common in ♂ of African or Mediterranean descent (malaria-endemic areas)

Hemolysis precipitated by drugs

• sulfonamides

• dapsone

• nitrofurantoin

• rasburicase

• primaquine

• doxorubicin

• methylene blue)

• infxn,

• DKA,

• foods (favism, NEJM 2018;378:60)

• Diagnosis-Glucose-6-phosphate dehydrogenase