definition of primary myelofibrosis (PMF)

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🌱 來自: primary myelofibrosis (PMF)

definition of primary myelofibrosis (PMF)🚧 施工中

definition of primary myelofibrosis (PMF)

• Clonal myeloproliferation with reactive marrow fibrosis & extramedullary hematopoiesis

• Prefibrotic stage (pre-PMF): megakaryocyte prolif, grade 1 reticulin fibrosis, ↑ BM cellularity. Compared w/ ET, pre-PMF has ↑ thrombosis, ↑ progression, ↓ survival (Blood 2012;120:569).