NOTE

🌱 created from: palliative_intent-of-hnscc

keynote-040

In patients with recurrent or metastatic head-and-neck squamous cell carcinoma, pembrolizumab monotherapy resulted in a clinically meaningful prolongation of overall survival compared to standard-of-care therapy (8.4 vs. 6.9 months) with a favourable safety profile, supporting its further evaluation as a monotherapy and in combination therapy in earlier stages of disease.

1.Cohen EEW, Soulières D, Tourneau CL, et al. Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study. The Lancet. 2019;393(10167):156-167. doi:10.1016/S0140-6736(18)31999-8