Info

🌱 來自: Histopathologic classification of LN

Advanced sclerosing LN

- Patients with advanced sclerosing glomerulonephritis usually display slowly progressive kidney dysfunction in association with proteinuria and a relatively bland urine sediment.

• Class VI disease is → characterized by global sclerosis of more than 90 percent of glomeruli.
• It represents healing of prior inflammatory injury, as well as the advanced stage of chronic class III, IV, or V lupus nephritis (LN).
• Active glomerulonephritis should not be observed.
• A retrospective study found that 4 percent of 169 kidney biopsies from patients with LN were classified with type VI disease [114].
• Identification of this lesion is → important since immunosuppressive therapy is → unlikely to be beneficial.