Paraneoplastic syndromes

內分泌、肌肉、神經、血液

Endo

SIADH (SCLC); ACTH (SCLC) → Cushing’s; PTH-rP (SCC) → hyperCa

Skeletal

• digital clubbing (NSCLC),
• hypertrophic pulm osteoarthropathy (adenocarcinoma) = symmetric polyarthritis and proliferative periostitis of long bones

Neuro (SCLC)

• Eaton-Lambert
• peripheral neuropathy (anti-Hu, anti-PCA-2, anti-CRMP5),
• cerebellar degeneration (anti-Hu, anti-Yo, anti-Ri, anti-Tr),
• encephalomyelitis (anti-Hu, anti-Ma1/2, anti-CRMP5)

Hematologic

• hypercoagulable state (adenocarcinoma)
• DIC