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Revised International Staging System

  • Serum albumin >3.5 g/dL
  • Serum beta 2 (β2)- microglobulin <3.5 mg/L
  • No high-risk cytogenetic features
  • Normal serum lactate dehydrogenase level

Stage II

Neither stage I nor stage III

Stage III

Both of the following:

  • Serum beta 2 (β2)- microglobulin >5.5 mg/L
  • AND one of the following
    • High-risk cytogenetics: t(4;14), t(14;16), del(17p)
    • Elevated serum lactate dehydrogenase level