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🌱 來自: molecular_pathogenesis-of-head_and_neck_squamous_cell_cancer

p16

p16 is a protein that plays a crucial role in head and neck cancer (HNC). Here are some key points about p16 in HNC:

1. p16 as a Surrogate Marker of HPV Infection:

   • HPV-positive tumors are less likely to harbor p53 mutations[1].

2. p16 Expression and Clinicopathological Parameters:

   • A study found a statistically significant direct association between p16 expression and age, site of the tumor, abnormal sexual habits, and lymph node involvement[1].
   • p16 expression was positively correlated with sex and site of the primary tumor, but not with age[1].

3. p16 and HPV Discordance:

   • Discordance between p16 and HPV DNA or RNA status exists in some patients with oropharyngeal cancer, which has significant implications for prognosis[2].
   • The controversy surrounding the prognostic significance of this discordant group has been addressed through a large, multicentre study that found substantial variations in survival outcomes[2].

4. p16 in Oropharyngeal Cancer:

   • p16 immunohistochemistry is widely used as a biomarker assay for inferring HPV causation in oropharyngeal cancer[2].
   • The study highlights the importance of accurately classifying patients with oropharyngeal cancer to guide treatment decisions and patient counselling[2].

These findings emphasize the importance of p16 expression in understanding the etiology and prognosis of head and neck cancers, particularly in the context of HPV infection.

Citations: [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272494/ [2] https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045%2823%2900013-X/fulltext [3] https://www.mdpi.com/1959460