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🌱 來自: colorectal cancer

Heritable Gastrointestinal Neoplasia Syndromes

Adenoma

• Familial adenomatous polyposis

  • Distribution of Polyps: Large intestine
  • Histologic Type: Adenoma
  • Malignant Potential: Common
  • Associated Lesions: None

• Gardner’s syndrome

  • Distribution of Polyps: Large and small intestines
  • Histologic Type: Adenoma
  • Malignant Potential: Common
  • Associated Lesions: Osteomas, fibromas, lipomas, epidermoid cysts, ampullary cancers, congenital hypertrophy of retinal pigment epithelium
  • Gardner

• Turcot’s syndrome

  • Distribution of Polyps: Large intestine
  • Histologic Type: Adenoma
  • Malignant Potential: Common
  • Associated Lesions: Brain tumors

• MYH-associated polyposis

  • Distribution of Polyps: Large intestine
  • Histologic Type: Adenoma
  • Malignant Potential: Common
  • Associated Lesions: None

• Lynch syndrome (nonpolyposis syndrome)

  • Distribution of Polyps: Large intestine (often proximal)
  • Histologic Type: Adenoma
  • Malignant Potential: Common
  • Associated Lesions: Endometrial and ovarian tumors (most frequently), gastric, genitourinary, pancreatic, biliary cancers (less frequently)

Hamartoma 大多良性

• Peutz-Jeghers syndrome

  • Distribution of Polyps: Small and large intestines, stomach
  • Histologic Type: Hamartoma
  • Malignant Potential: Rare
  • Associated Lesions: Mucocutaneous pigmentation; tumors of the ovary, breast, pancreas, endometrium -Peutz-Jeghers syndrome

• Juvenile polyposis

  • Distribution of Polyps: Large and small intestines, stomach
  • Histologic Type: Hamartoma, rarely progressing to adenoma
  • Malignant Potential: Rare
  • Associated Lesions: Various congenital abnormalities
  • Juvenile polyps