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Immunohistochemical algorithms of Diffuse large B-cell lymphoma
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to distinguish phenotype have been developed but reliability is → unclear; not routinely used to guide management.
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GCB-like defined by HANS criteria CD10+ or BCL6+/MUM1− (>30% staining for each) (Blood 2004;103:275)
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the five histopathological subtypes of DLBCL according to WHO classification
- Centroblastic
- immunoblastic
- T-cell/histiocytic-rich
- anaplastic
- and plasmablastic variants
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| CD 10 - | BCL6 + | BCL6 - |
|---|---|---|
| MUM + | non-GCB | GCB |
| MUM - | GCB | GCB |
TLDR: - + + : non GCB