Info
clinical manifestations of systemic sclerosis
- Skin manifestations of systemic sclerosis → C,S,T
- Arteries
- Raynaud’s phenomenon (80%); digital or visceral ischemia
- Renal manifestations of systemic sclerosis → R
- GI (>80% of Patients)
- GERD and erosive esophagitis,
- esophageal dysmotility (dysphagia, odynophagia, aspiration), → E
- gastric dysmotility,
- small intestinal dysmotility (malabsorption, bacterial overgrowth, bloating)
- Musculoskeletal
- Arthralgias/arthritis;
- myositis;
- joint contractures;
- tendon friction rubs
- Cardiac
- Myocardial fibrosis;
- pericardial effusion;
- conduction abnormalities;
- CAD
- Pulmonary
- Pulmonary fibrosis (typically develops within 4 years);
- pulmonary arterial hypertension (typically develops after many years);
- #1 cause of mortality
- Endocrine
- Amenorrhea and infertility common;
- thyroid fibrosis ± hypothyroidism