Plain radiographs: normal early in disease; lytic lesions seen after 2–6 wk
MRI: preferred imaging study (overall Se 90%, Sp 82%; Archives 2007;167:125)
CT: can demonstrate periosteal reaction and cortical and medullary destruction
CT & MRI very Se but ↓ Sp; false ⊕ if contig focus w/ periosteal reaction, Charcot Δs
Radionuclide imaging: very Se but non-Sp (false ⊕ if soft-tissue inflammation)
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Plain x-rays: normal in the beginning stages of the disease; after 2-6 weeks, lytic lesions can be seen.
MRI: the preferred imaging study. It is very accurate in identifying the disease (overall Se 90%, Sp 82%).
CT: can show periosteal reaction, cortical and medullary destruction.
CT and MRI are very accurate in identifying the disease, but can sometimes give false positive results if there is a contigous focus with periosteal reaction or Charcot lesions.
Radionuclide imaging: very accurate in identifying the disease, but can sometimes give false positive results if there is soft-tissue inflammation.