Info

🌱 來自: acute lymphoblastic leukemia (ALL)

classification of acute lymphoblastic leukemia (ALL)

Lymphoblastic neoplasms may present as

• acute leukemia

  • (ALL)
  • w/ >20% BM blasts

• lymphoblastic lymphoma

  • (LBL, more common in T-cell)
  • w/ mass lesion w/ <20% BM blast

• Morphology:

  • no granules (granules seen in myeloid lineage)

• Cytochemistry:

  • ⊕ terminal deoxynucleotidyl transferase (TdT)
    • in 95% of ALL, MPO negative

Immunophenotype

• Precursor: CD34, TdT
• B: CD19; variable CD10, CD22, CD79a
• T: CD1a, CD2, cytoplasmic CD3, CD5, CD7