• from: platelet disorders 󰒖

Approach to thrombocytopenia

• isolated thrombocytopnea otherwise normal complete 🩸 count and smear

  • autoimmune disease? meds? infection?
    • ITP
    • 2ndary immune, medications, infections

• abnromal complete 🩸 count and/or smear

  • spherocytes: Evan’s synd.
  • schistocytes:
    • disseminated intravascular coagulation
    • hemolytic uremic syndrome/thrombotic thrombocytopenic purpura
    • Mech. circulation support
  • pancytopenia and or blasts:
    • aplastic anemia
    • myelodysplastic syndrome MDS
    • leukemia
  • leukoerythroblastic: meylophthisis a.k.a fibrosis

• TLDR:

• Step 1 if the count less than 150k, than check if anemia

• if anemia, do bone marrow

• else check smear:

  • if Fragmented RBC: MAHA
  • else: survey for 2nd (Drug, Infection, and Congential)
  • then ITP