Classification-autoimmune hepatitis (AIH)

(J Hep 2015;62:S100, World J Gastro 2015;21:60)

• Type 1 autoimmune hepatitis: anti-smooth muscle Ab (ASMA), ANA; anti-soluble liver antigen (anti-SLA), a/w more severe disease and relapsing disease (found in 10-30% Pts), IgG often ↑
• Type 2 autoimmune hepatitis: anti-liver/kidney microsome 1 (anti-LKM1); anti-liver cytosol type 1 (anti-LC-1)
• Overlap syndrome: AIH + PBC (suspect if ⊕ AMA or ⊕ histology → “autoimmune cholangitis”)
• Drug-induced: minocycline, nitrofurantoin, infliximab, hydralazine, α-methyldopa, statins