Info
🌱 來自: platelet disorders
Normal platelet function-hemostasis
- Production:
- Regulated by hormone TPO secreted from liver & acting on megakaryocytes in BM;
- 1 × 1011 produced daily, circulate for 7-10 d
- Adhesion:
- Endothelial injury → plt activation & binding via GPIb-IX to VWF or via GPVI, integrin α2β1 to the subendothelial matrix (eg, collagen)
- Aggregation:
- Activated GPIIb-IIIa binds VWF & fibrinogen to form clumps → ADP & serotonin released from granules → additional plt recruited
- Pseudothrombocytopenia:
- Falsely ↓ plt count due to plt clumping, seen on peripheral smear; mgmt: Collect blood in non-EDTA, citrate-or heparin-containing tube