ENL 2017 Genetic Risk Classification

Info

🌱 來自: acute myelogenous leukemia (AML)

ENL 2017 Genetic Risk Classification

 (Blood 2017;129:424)

Favorable 🟢

• APL: t(15;17); PML-RARa;

• t(8;21): RUNX1-RUNX1T1; inv(16): CBFB-MYH1;

• mutated NPM1 w/o FLT3-ITD or w/ FLT3-ITDlow*;

• biallelic mutation in CEBPA

Intermediate 🟡

• FLT3-ITDlow*; mutated NPM1 & FLT3-ITDhigh*; t(9;11): MLL-MLLT3;

• cytogenetic abnl not classified as favorable or adverse, including normal karyotype w/o mutations in FLT3-ITD & NPM1

Adverse 🔴

• -5 or del(5q); -7; -17/abn(17p); complex or monosomal karyotype;

• t(6;9): DEK-NUP214; t(9;22) BCR-ABL1; inv(3): GATA2-MECOM;

• wildtype NPM1 & FLT-ITDhigh*; mutated TP53, RUNX1, ASXL1

---

• low/high: FLT3-ITD variant allele frequency (VAF); reflects burden of mut. leukemic cells