Preventive treatment of Migraine

• Recommended for patients adversely affected on ≥2 days per month despite optimized acute therapy

First-line medication

• Beta blockers (propranolol, metoprolol, atenolol, bisoprolol)
• Topiramate
• Candesartan

Second-line medication

• Flunarizine
• Amitriptyline
• Sodium valproate

Third-line medication

• CGRP monoclonal antibodies