NOTE

🌱 created from: biology_of_chronic_myelogenous_leukemia

philadelphia_chromosome

• BCR–ABLE1 gene fusion,
• reciprocal translocation between chrs 9 (ABLE1) & 22 (BCR)
  • −> t(9;22)(q34;q11),
• identified by karyotype/FISH (noncryptic) in 95% of cases
  • → encodes constitutively activated tyrosine kinase central to CML pathogenesis → progression to AP/BC based on clonal evolution,
  • likely additional molecular changes,
  • ABLE kinase muts