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🌱 來自: Diagnosis of Thrombotic microangiopathies

HELLP syndrome

• hemolysis,
• elevated liver enzymes,
• low platelets

Laboratory criteria for diagnosis — We require the presence of all of the following criteria to diagnose HELLP (Tennessee classification) [21]:

Hemolysis, established by at least two of the following:

• Peripheral smear with schistocytes and burr cells (picture 2)

• Serum bilirubin ≥1.2 mg/dL (20.52 micromol/L)

• Low serum haptoglobin (≤25 mg/dL) or lactate dehydrogenase (LDH) ≥2 times the upper level of normal (based on laboratory-specific reference ranges)

• Severe anemia, unrelated to blood loss

Elevated liver enzymes:

• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≥2 times the upper level of normal (based on laboratory-specific reference ranges)

• Low platelets: <100,000 cells/microL

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• 微血管溶血性貧血患者的外周血塗片
• 顯著的紅細胞碎裂
• 多個頭盔狀細胞（箭頭）
• 其他碎裂紅細胞（小箭頭）
• 微球細胞（大箭頭）
• 減少的血小板數量
• 中心的大血小板（虛線箭頭）提示由於破壞增強導致血小板減少