Vascular Beds Affected by Inherited and Acquired Hypercoagulable States
Inher.
Venous
- Factor V Leiden
- Prothrombin mutation ↓ protein C, S or AT III
Venous and Arterial
- Hyperhomocysteinemia (inherited or acquired)
- Dysfibrinogenemia
Acquired
Venous
- Stasis: immobilization, surgery, CHF
- Malignancy
- Hormonal: OCPs, HRT, tamoxifen, pregnancy
- Nephrotic syndrome## Venous
Venous and Arterial
- Platelet defects: myeloproliferative disorders, HIT, PNH (although venous >arterial)
- Hyperviscosity: polycythemia vera, Waldenström’s -macroglobulinemia, sickle cell, acute leukemia
- Vessel wall defects: vasculitis, trauma, foreign bodies
- Others: antiphospholipid syndrome, IBD