NOTE

🌱 created from: cryoglobulinemia

classification_and_types_of_cryoglobulinemia

• Classification system by Brouet et al. in 1974 based on isotype(s) of immunoglobulins
  • Type I: Monoclonal immunoglobulin (IgM, IgG, or IgA)
  • Type II: Polyclonal IgG plus monoclonal IgM with rheumatoid-factor activity
  • Type III: Polyclonal IgG, polyclonal IgM, or both; mixed cryoglobulinemias