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🌱 來自: rheumatoid arthritis

definition and epidemiology of rheumatoid arthritis

• Chronic, symmetric, and potentially destructive inflammatory polyarthritis characterized by proliferative synovial tissue (pannus) formation in affected joints
• Pathogenesis involves overproduction of TNF, IL-1, and IL-6 (∴ used as drug targets)
• Risk stems from combination of genetics (~50% of risk), environmental influences (eg, smoking, silica dust), and Pt factors (periodontal disease, Δs in gut microbiome)
• HLA-DRB1 haplotype a/w disease suscept., severity, & response to Rx (JAMA 2015;313:1645)
• Prevalence =
  • 1/100 adults and 1/20 ♀ >70 y;
  • ♀ to ♂ ratio = 3:1;
  • peak incidence 50-75 y