Info

🌱 來自: breast cancer

Molecular pathology-of-breast cancer

• ER+: >1% PR+: > 1%

• Other IHC markers: Mammaglobin, AR, CK5, CK6, CK17

• HER2 testing: HER2/neu gene amplification observed in 20-30% of invasive breast CA. Assoc w/ worse prog (↑ risk of dz progression, ↓ OS) if untreated

• IHC: 3+ = HER2+; 0-1+ = HER2−; 2+ = equivocal → refer for FISH

• FISH: Positive if HER2/CEP17 ratio ≥2 & copy number/cell ≥4. If discordant, see ASCO/CAP 2018 guidelines (J Clin Oncol 2018;36:2105)

• Allred score: total score (TS) = percentage score (PS) + intensity score (IS) (range 0, 2-8).

Molecular & Receptor Classification (JCO 2010;28:1684)

• Breast Cancer Molecular Subtyping
• Nottingham Prognostic Index Score