Info
octreotide 🚧
Sandostatin Injection” 100 mcg octreotide/1 mL/amp
常用劑量
SC (preferred), IV (over 3 mins), IVF (in NS or D5W 50 - 200 mL; infuse over 15 to 30 mins)
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Acromegaly, inadequate response to or ineligible for surgery, radiation, or bromocriptine mesylate: Initial, SC/IV 50mcg tid; maintenance, SC/IV 100- 500mcg tid.
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Carcinoid syndrome, metastatic, symptomatic treatment: Initial, 100- 600 mcg/day in 2-4 divided doses for 2wks; maintenance, 450 mcg/day (range 50-1500 mcg).
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VIPomas (Vasoactive intestinal peptide-secreting tumor) associated diarrhea: Initial, 200-300 mcg/day in 2-4 divided doses for 2wks (range 150- 750 mcg/day); then adjust dosage on an individual basis, usually ≦450 mcg/day.
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Complications following pancreatic surgery: SC, 100 mcg tid for 7 successive days, starting on the day of operation at least 1hr before laparotomy.
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Esophageal varices bleeding (unlabeled use):
warning
25-100 mcg IV bolus (usually: 50 mcg = 半支) followed by contnuous IVF 25-50 mcg/hr for 2-5 days. 血沒停，可再打半支 bolus
劑量調整
Dosage in renal impairment:
- Mild to severe impairment: No dosage adjustment data available.
- Dialysis-dependent impairment: A dosage adjustment may be needed since clearance is reduced by ~50%.
Dosage in hepatic impairment:
No dosage adjustment provided in manufacturer’s labeling. Half-life is prolonged and total body clearance is decreased in patients with cirrhosis and fatty liver disease.
給藥注意事項
- For direct IV, octreotide should be administered undiluted over 3 min.
- For intermittent IV infusion, octreotide may be diluted in 50- 200 mL NS or D5W and infused over 15-30 min.