Info
🌱 來自: Huppert’s Notes
WBC Disorders🚧 施工中
WBC Disorders
Leukopenia
• Definition: Low WBC (<4K/μl). If absolute neutrophil count (ANC) <1000/μl, that is called neutropenia and carries an increased risk of infection. Severe neutropenia is when the ANC <500/μl.
• Differential diagnosis**:**
- Infection: Often causes leukocytosis, but can cause leukopenia
- Malignancy: Bone marrow infiltration
- Inflammatory/autoimmune conditions: SLE, others
- Medications: Chemotherapy, antibiotics, anti-epileptics, and substances (e.g., alcohol) can all be myelosuppressive
• Treatment: Treat underlying condition. Patients with ANC <500/μl typically require urgent workup even if asymptomatic.
Leukocytosis
• Definition: High WBC (>10K/μl)
• Differential diagnosis:
- Infection
- Malignancy: If very high WBC, consider acute leukemia
- Inflammatory/autoimmune conditions
- De-margination: Stress response, steroids
• Treatment: Treat underlying condition. Leukocytosis itself does not require treatment except in hyperleukocytosis related to leukemia, for which hydroxyurea and leukapheresis may be indicated.