Info

🌱 來自: Metastatic Colon Cancer

Oxaliplatin

• (Eloxatin)
• Dosing: 85-130 mg/m2 IV every 2-3 wks. Renal: CrCl <30 mL/min: reduce dose to 65 mg/m2. Reduce dose for prolonged neuropathy & grade 3-4 GI & cell count tox
  • 85mg in mCRC
• PK/PD: Highly protein bound (>90%), hydrolyzed to reactive metabolites, renal excretion, T1/2 391 h (platinum metabolites)
• AEs:
  • Neurotoxicity (DLT) 🖐️
  • myelosuppression 󰒖, 🩸
  • pharyngolaryngeal dysesthesia 😆
  • peripheral neuropathy, 🤌
  • ↑ LFTs, 🥭
  • ↑ SCr, 🍌
  • fever 🤯
• DDI: No significant drug interactions
• Clinical pearls:
  • 🥶Cold temperatures can worsen peripheral neuropathy