Info
🌱 來自: Fluorouracil
AEs of Fluorouracil
💩👄🤮🩸🤞🫀👁️🖐️🦶😇🐌
Dependent on dose & administration (IV bolus vs. IV continuous infusion),
- diarrhea (DLT), 💩
- mucositis (DLT), 👄
- N/V (low emetogenic potential), 🤮
- myelosuppression (bolus > continuous infusion), 🩸
- neurotoxicity, 🤞
- coronary artery vasospasm,🫀
- conjunctivitis, 👁️
- hand-foot syndrome (continuous infusion > bolus) 🖐️ 🦶
- Palmar-plantar erythrodysesthesia (hand-foot syndrome)
- alopecia, 😇
- nail changes 🐌
- Myelosuppression
- Cardiotoxicity
- Higher toxicity in patients with dihydropyrimidine dehydrogenase deficiency
- Hepatotoxicity
- Hyperammonemic encephalopathy