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🌱 來自：Preoperative Chemotherapy for Operable Breast Cancer

Pembrolizumab

( Keytruda )

• Mechanism: Binds to PD-1
• Dosing: 2 mg/kg IV every 3 wks, tx can be held due to ↑ liver enzymes
• PK/PD: T1/2 ∼27 d
• AEs: Immune-mediated tox, fatigue, rash, metabolic abnormalities, lymphocytopenia
• DDI: No known pathways of metabolism
• Clinical pearls: Tx immune-related tox w/ steroids (prednisone 1-2 mg/kg/d)

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• systemic therapy of breast cancer
• prechemo_TNBC
• irAE
• Stage II-of-Preoperative Chemotherapy for Operable Breast Cancer
• Stage III-of-Preoperative Chemotherapy for Operable Breast Cancer
• Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
• PD-L1
• Overview-immunotherapy and cellular therapy
• NSCLC Treatment
• Metastatic Colon Cancer
• KEYNOTE-177
• KEYNOTE-181
• Immunotherapy
• Amivantamab
• Adeno or Other in Stage IV NSCLC Treatment