Digoxin

• 0.5 then 0.25 mg q6h

• up to 1.5 mg/24 h

• 0.125-0.375 mg

• qd (adjust for CrCl)

• Consider in HF or low BP

• Poor exertional HR ctrl

• 23% ↓ HF hosp., no ∆ mort (NEJM 1997;336:525); ? ↑ mort w/ ↑ levels (NEJM 2002;347:1403); optimal 0.5–0.8 ng/mL (JAMA 2003;289:871)