Info

🌱 來自: polycythemia vera (PV)

etiologies of erythrocytosis

(absolute ↑ RBC)

• Acquired 1°: PV (usually JAK2 +) or other MPN
• Germline 1°: Chuvash (hypoxia-sensing disorder due to _VHL_mutation),EGLN mutations
• Secondary: carboxyhemoglobinemia; hypoxia (OSA, COPD**); inappropriate erythropoietin** (renal, hepatic); Cushing’s syndrome
• Mimics: relative ↑ RBC (↓ plasma) due to dehydration; “stress” erythrocytosis (Gaisböck’s syndrome)