Info
Definition and epidemiology of systemic lupus erythematosus
| Feature | Value |
|---|---|
| Disease | Multisystem inflammatory autoimmune disease |
| Clinical manifestations | Broad spectrum, including skin, joints, kidneys, blood, nervous system, and heart |
| Associated with | Antinuclear antibody (ANA) production |
| Prevalence | 5-35/10,000 in U.S. |
| Predominant sex | Women (♀:♂ ratio = 8:1) |
| Age of onset | 2nd to 4th decade |
| Ethnicity | African Americans affected 2-4× as often as Caucasians |
| Genetics | Complex genetics; some HLA association; rarely C1q & C2 deficiency |
Source: Nat Rev Rheumatol 2021;17:515