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Definition and classification system of seronegative spondyloarthritis

  • Spondyloarthritis (SpA):
    • group of inflammatory disorders that share common clinical manifestations:
      • inflammatory spine disease,
      • peripheral arthritis,
      • enthesitis (see below),
      • and extra-articular manifestations (primarily ocular and skin disease)
  • Seronegative = absence of autoantibodies
  • Subtypes:
    • ankylosing spondylitis (AS),
    • psoriatic (PsA),
    • reactive (ReA),
    • IBD-assoc,
    • juvenille SpA,
    • and undifferentiated.
  • Distinguished by axial vs. peripheral predominant involvement.