Info
WHO 2016 Classification of Myeloid Neoplasms & Acute Leukemia
- Acute myeloid leukemia
- Clonal myeloid stem cell (SC) disorder w/ ≥20% blasts
- Myelodysplastic syndromes
- Dysplastic clonal myeloid SC disorder → cytopenias; <20% blasts, risk of leukemic transformation
- Myeloproliferative neoplasms
- Nondysplastic multipotent myeloid SC clonal expansion
- MDS/MPN neoplasms
- Features of MDS & MPN (eg, CMML, atypical CML)
- Myeloid/lymphoid malig. w/ eos & rearrangements of PDGFR or FGFR1 or w/ PCM1-JAK2
- May be responsive to TKI therapy (eg, imatinib) for PDGFR rearrangement
- Mastocytosis
- Clonal mast cell disorder, assoc w/ KIT mutations
- Myeloid neoplasms w/ germ line predisposition
- MDS, MDS/MPN, acute leukemias in background of predisposing germline mutations (eg, DDX41)