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🌱 來自: acute coronary syndromes

Other early adjunctive therapy of acute coronary syndromes

• High-intensity statin therapy (eg, at ↣ orva 80 mg qd; PROVE-IT TIMI 22, NEJM 2004;350:1495);
  • ↓ ischemic events w/ benefit emerging w/in wks (JAMA 2001;285:1711 & JACC 2005;46:1405);
  • ↓ peri-PCI MI (JACC 2010;56:1099);
  • ? ↓ contrast-induced nephropathy (NEJM 2019;380:2156)
• Ezetimibe:
  • ↓ CV events when added to statin (IMPROVE-IT, NEJM 2015;372:2387)
• ACEI/ARB:
  • start once hemodynamics and renal function stable (hold if anticipate CABG)
  • Strong indication for ACEI/ARB if
  • heart failure,
  • EF <40%,
  • HTN,
  • DM,
  • CKD; ~10% ↓ mortality,
  • greatest benefit in ant. STEMI or prior MI (Lancet 1994;343:1115 & 1995;345:669)
  • IABP as early adjunctive therapy of acute coronary syndromes 󰒖: can be used for refractory angina when PCI not available