Info

HyperVISCOSITY syndrome

Diagnostic Considerations

  • Multiple myeloma
  • Waldenström macroglobulinemia
  • Leukostasis (see the Medscape Reference article Oncologic Emergencies, under Hyperleukocytosis)
  • Polycythemia
  • Thrombocytosis

management

  • Plasmapheresis is the treatment of choice for initial management and stabilization of HVS from elevated immunoglobulin levels. [5] Leukapheresis, plateletpheresis, and phlebotomy are indicated for HVS from leukostasis, thrombocytosis, and polycythemia, respectively.