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treatment of waldenstrom’s macroglobulinemia (WM)

  • Hyperviscosity:

    • plasmapheresis;
    • limit transfusions if possible (worsen hyperviscosity)
  • Sx (eg, prog. anemia):

    • ritux ± chemo (eg, bendamustine, Cy, etc.);
    • ritux + ibrutinib (NEJM 2018;378:2399);
    • zanubrutinib (Lancet Haem 2020;7:e837);
    • everolimus or HSCT in salvage