Ticagrelor

180 mg × 1 → 90 mg bid Reversible, but wait 3–5 d prior to surg. Antidote being developed (NEJM 2019;380:1825). More rapid and potent plt inhib c/w clopi 16% ↓ CVD/MI/stroke & 21% ↓ CV death c/w clopi; ↑ non-CABG bleeding (NEJM 2009;361;1045) Given upstream or at time of PCI Dyspnea (but SaO2 & PFTs nl) & ventricular pauses