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IDH1_IDH2 mutation
- 20% of AML
- isocitrate dehydrogenase (IDH) genes,
- IDH1 or IDH2.
adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.
- ivosidenib
- enasedinib
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adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.