Info

multiple endocrine neoplasia type 2

(RET proto- oncogene)

  • MEN2A
    • 甲: Medullary thyroid carcinoma (MTC) (~99%)
    • 鉻: Pheochromocytoma (~50%)
    • 副甲: Parathyroid hyperplasia → hypercalcemia (15-20%)

multiple endocrine neoplasia type 2b a.k.a type 3

  • MEN2B (RET proto- oncogene)

    • 甲: Medullary thyroid carcinoma (MTC) (~99%)
    • 鉻: Pheochromocytoma (~50%)
    • Mucosal and gastrointestinal neuromas, marfanoid habitus