Info

clinical manifestations of overview of lymphoma and CLL

Lymphadenopathy (usually nontender)

HL 🦉

  • superficial
    • usually cervical/supraclavicular
  • ± mediastinal LAN
  • nodal disease
    • orderly
    • anatomic spread to adjacent nodes

NHL 🍋

  • diffuse
  • nodal and/or extranodal disease with noncontiguous spread
  • symptoms reflect involved sites (abdominal fullness, bone pain)

Constitutional (“B”) symptoms:

  • fever (>38°)
  • drenching sweats
  • ↓ weight (>10% in 6 mo)

HL:

  • periodic
  • recurrent “Pel-Ebstein” fever
  • 10–15% have pruritus
  • ~35% “B” symptoms

NHL:

  • “B” symptoms vary between subtypes
  • ~15–50%